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FLASH GENE
Symbol BFAR contributors: mlc - updated : 07-01-2008
HGNC name bifunctional apoptosis regulator
HGNC id 17613
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • RING finger domain
  • a sterile alpha motif (SAM), required for its interactions with BCL2 and BCLX(L) and for suppression of Bax-induced cell death in both mammalian cells and yeast
  • a DED-like domain responsible for its interaction with DED-containing procaspases and suppression of Fas-induced apoptosis
    • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    text anchored in intracellular membranes where BCL2 resides
    basic FUNCTION
  • potential adhesion receptor, putatively involved in neural crest cells migration
  • inhibitor of Bax-induced apoptosis, involved in the regulation of neuronal survival
  • scaffold protein capable of bridging two major apoptosis pathways
  • functions as an ER-associated RING-type E3 ligase, interacting with TMBIM6, and promotes proteasomal degradation of TMBIM6
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS