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FLASH GENE

Symbol

BFAR

contributors: mlc - updated : 07-01-2008

HGNC name	bifunctional apoptosis regulator
HGNC id	17613

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine thyroid       highly Hearing/Equilibrium ear       highly Nervous brain       highly Skin/Tegument skin       highly

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	RING finger domain
	a sterile alpha motif (SAM), required for its interactions with BCL2 and BCLX(L) and for suppression of Bax-induced cell death in both mammalian cells and yeast
	a DED-like domain responsible for its interaction with DED-containing procaspases and suppression of Fas-induced apoptosis

HOMOLOGY

Homologene

FAMILY

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
text	anchored in intracellular membranes where BCL2 resides

basic FUNCTION	potential adhesion receptor, putatively involved in neural crest cells migration
	inhibitor of Bax-induced apoptosis, involved in the regulation of neuronal survival
	scaffold protein capable of bridging two major apoptosis pathways
	functions as an ER-associated RING-type E3 ligase, interacting with TMBIM6, and promotes proteasomal degradation of TMBIM6

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS