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FLASH GENE
Symbol TMX4 contributors: mct - updated : 14-11-2019
HGNC name thioredoxin-related transmembrane protein 4
HGNC id 25237
Location 20p12.3      Physical location : 7.961.715 - 8.000.393
Synonym name
  • thioredoxin domain containing 13
  • protein disulfide isomerase family A, member 14
  • Synonym symbol(s) DJ971N18.2, KIAA1162, UNQ475/PRO938, TXNDC13, PDIA14
    DNA
    TYPE functioning gene
    STRUCTURE 38.68 kb     8 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 2368 38 349 - 2010 20056998
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly Homo sapiens
     vessel   highly Homo sapiens
    Digestiveliver   highly Homo sapiens
    Reproductivemale systemtestis  highly Homo sapiens
    Urinarykidney   highly Homo sapiens
    Visualeye   moderately Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervousperipherous    Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a single ER-luminal thioredoxin-like domain, which, in contrast with similar domains in other PDIs, is mainly oxidized in living cells
  • a Trx-like domain that faced the ER lumen, with N-glycosylation site
  • an RQR motif in the TMX4 cytosolic domain was reported to be essential for its ER localization because the deletion of RQR motif caused the transport of TMX4 to the cell surface
  • a typical C-terminal di-lysine retrieval signal, in the cytosol
  • the cytoplasmic tail has a conserved di-arginine motif of the RXR type
  • HOMOLOGY
    Homologene
    FAMILY
  • thioredoxin family, PDI family
  • CATEGORY transport
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,nuclear envelope,int
    text
  • integral to membrane
  • type I membrane protein
  • N-glycosylated type I membrane protein that localizes to the ER
  • localize to the ER
  • MFSD10, TMX4, and ARL6IP6 likely residing in the inner nuclear membrane
  • basic FUNCTION
  • acting as a redox-active center
  • N-glycosylated type I membrane protein that localizes to the ER
  • could work as a reductase in the environment of the ER
  • role of TMX4 may be to enable protein folding in cooperation with these proteins consisting of folding complex in the ER
  • involved in productive folding together with calnexin and PDIA3
  • would be a reductase in the ER
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with calnexin, suggesting the possible involvement of TMX4 as a reductase in cooperation with TMX1 or PDIA3 in the calnexin folding complex
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in melanoma cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS