motifs/domains
| a single ER-luminal thioredoxin-like domain, which, in contrast with similar domains in other PDIs, is mainly oxidized in living cells |
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a Trx-like domain that faced the ER lumen, with N-glycosylation site |
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an RQR motif in the TMX4 cytosolic domain was reported to be essential for its ER localization because the deletion of RQR motif caused the transport of TMX4 to the cell surface |
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a typical C-terminal di-lysine retrieval signal, in the cytosol |
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the cytoplasmic tail has a conserved di-arginine motif of the RXR type |
SUBCELLULAR LOCALIZATION
| plasma membrane
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| intracellular
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
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| intracellular,nuclear envelope,int
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text
| integral to membrane |
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type I membrane protein |
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N-glycosylated type I membrane protein that localizes to the ER |
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localize to the ER |
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MFSD10, TMX4, and ARL6IP6 likely residing in the inner nuclear membrane |