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FLASH GENE
Symbol ZNF541 contributors: npt - updated : 19-05-2009
HGNC name zinc finger protein 541
HGNC id 25294
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two sant domains
  • C2H2-type zinc fingers
    • HOMOLOGY
    Homologene
    FAMILY
  • n-cor nuclear receptor corepressors family
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • mediating the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • ZNF541/KCTD19 signaling complex, acting as a key transcription regulator, plays an indispensable role in male fertility by regulating pachytene progression
    • INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
    • protein
  • association of KCTD19 with zinc finger protein 541 (ZNF541) and histone deacetylase 1 (HDAC1)
  • ZNF541 binds to and activates the expression of genes involved in meiosis and post-meiosis including KCTD19
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS