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FLASH GENE
Symbol ZNF541 contributors: npt - updated : 19-05-2009
HGNC name zinc finger protein 541
HGNC id 25294
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Skin/Tegumentskin    
Urinarykidney   lowly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two sant domains
  • C2H2-type zinc fingers
    • HOMOLOGY
    Homologene
    FAMILY
  • n-cor nuclear receptor corepressors family
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • mediating the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • ZNF541/KCTD19 signaling complex, acting as a key transcription regulator, plays an indispensable role in male fertility by regulating pachytene progression
    • INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
    • protein
  • association of KCTD19 with zinc finger protein 541 (ZNF541) and histone deacetylase 1 (HDAC1)
  • ZNF541 binds to and activates the expression of genes involved in meiosis and post-meiosis including KCTD19
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS