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FLASH GENE
Symbol GRID2IP contributors: mct - updated : 23-09-2011
HGNC name glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein 1
HGNC id 18464
Location 7p22.1      Physical location : 6.536.409 - 6.591.067
Synonym name delphilin
DNA
TYPE functioning gene
STRUCTURE 54.66 kb     22 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
22 - 4632 - 1211 - 2006 16835239
  • S-delphilin, palmitoylated at the N terminus, region spliced out in L-delphilin
  • facilitated the expression of GRID2 on the cell surface
  • associated with plasma membranes in COS cells and dendritic spines in hippocampal neurons
  • - - - - - - 2006 16835239
  • having an alternatively spliced N-terminal exons encoding an additional PDZ domain
  • formed clusters in soma and dendritic shafts
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrainhindbraincerebellum predominantly Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    NervousPurkinje cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a PDZ domain (codon 94-166)
  • a GRCAH domain (codon 204-269)
  • a formin homology domain that is thought to regulate actin dynamics, a FH1 domain (codon 559-621), and a FH2 domain
  • HOMOLOGY
    interspecies ortholog to rat Grid2ip
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • co-localizes with the GRID2 subunit at the Purkinje cell-parallel fiber synapses
  • basic FUNCTION unknown
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • GRID2-interacting protein, selectively expressed in Purkinje cell-parallel fiber synapses, and specifically interacting with the GRID2 C-terminus via its PDZ domain
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS