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FLASH GENE

Symbol

SNCA

contributors: mct - updated : 20-08-2017

HGNC name	synuclein, alpha (non A4 component of amyloid precursor)
HGNC id	11138

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

PARK1

related resource

Alpha - Synuclein Locus Mutation Database

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional   amplification     triplicated locus in Parkinson 4 (PARK4)

Susceptibility

to sporadic Parkinson disease (PD) to variability of age at onset of Parkinson's disease

Variant & Polymorphism SNP	"protective" genotype 259/259 of the PD-associated promoter repeat NACP-Rep1 is associated with lower protein levels in blood
	rs356219 risk allele in the SNCA gene significantly contributing to earlier age at onset

Candidate gene
Marker	increased SNCA and altered phagocytosis may provide a useful biomarker for human Parkinson disease
Therapy target
	System Type Disorder Pubmed neurology neurodegenerative Parkinson/dementia Parkinsonism secreted SNCA exerts toxicity through engagement, at least in part, of the Ca2+ homeostatic machinery, and therefore, manipulating Ca2+ signaling pathways might represent a potential therapeutic strategy for Parkinson disease

ANIMAL & CELL MODELS