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FLASH GENE

Symbol

YARS

contributors: mct/npt - updated : 29-10-2009

HGNC name	tyrosyl-tRNA synthetase
HGNC id	12840

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
SPECIAL FEATURE	arranged in tandem
STRUCTURE	42.80 kb     13 Exon(s)

Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_003680 13 - 3117 NP_003671 - 528 - Wakasugi (1999)

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive stomach       moderately Lymphoid/Immune lymph node       highly   spleen       moderately Nervous brain         Reproductive female system uterus cervix   highly Visual eye       moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone       Nervous peripherous

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	an N-terminal catalytic domain
	a tRNA-binding domain
	a catalytic-domain surface helix, next to the active site, recruited for interleukin-8-like cytokine signaling (Kapoor 2009)
	a central anticodon recognition domain
	a C-terminal EMAP II-like (endothelial monocyte-activating polypeptide II) domain (Storkebaum 2009)

conjugated

Other

mono polymer

homomer , dimer

HOMOLOGY

interspecies

ortholog to murine Yars

Homologene

FAMILY

class-I aminoacyl-tRNA synthetase family

CATEGORY

enzyme , signaling cytokine

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,cytoplasm
text	soluble fraction

basic FUNCTION	acting as a tyrosine-tRNA ligase
	acting as an interleukin-8-like cytokine by binding to the interleukin-8 type A receptor via its catalytic amino-terminal domain
	playing a role of endothelial monocyte-activating polypeptide II-like in its carboxy-terminal domain
	catalyze aminoacylation and is also procytokine activated by natural fragmentation (Yang 2007)

CELLULAR PROCESS	cell life, cell death/apoptosis
	protein, translation/synthesis
	cell migration & motility

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

a component

acetylation

INTERACTION

DNA

RNA

tRNA

small molecule	nucleotide,
	ATP

protein

interleukin-8 receptor

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

DICMTC

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS