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FLASH GENE

Symbol

YARS

contributors: mct/npt - updated : 29-10-2009

HGNC name	tyrosyl-tRNA synthetase
HGNC id	12840

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	DICMTC Charcot-Marie-Tooth, dominant intermediate C
Location	1p35.1      Physical location : 33.240.839 - 33.283.633
Synonym name	tyrosine tRNA ligase 1, cytoplasmic
Synonym symbol(s)	YRS, YTS, tyrRS, TYRS
EC.number	6.1.1.1

DNA

TYPE	functioning gene
SPECIAL FEATURE	arranged in tandem
STRUCTURE	42.80 kb     13 Exon(s)

Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_003680 13 - 3117 NP_003671 - 528 - Wakasugi (1999)

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive stomach       moderately Lymphoid/Immune lymph node       highly   spleen       moderately Nervous brain         Reproductive female system uterus cervix   highly Visual eye       moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone       Nervous peripherous

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	an N-terminal catalytic domain
	a tRNA-binding domain
	a catalytic-domain surface helix, next to the active site, recruited for interleukin-8-like cytokine signaling (Kapoor 2009)
	a central anticodon recognition domain
	a C-terminal EMAP II-like (endothelial monocyte-activating polypeptide II) domain (Storkebaum 2009)

conjugated

Other

mono polymer

homomer , dimer

HOMOLOGY

interspecies

ortholog to murine Yars

Homologene

FAMILY

class-I aminoacyl-tRNA synthetase family

CATEGORY

enzyme , signaling cytokine

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,cytoplasm
text	soluble fraction

basic FUNCTION	acting as a tyrosine-tRNA ligase
	acting as an interleukin-8-like cytokine by binding to the interleukin-8 type A receptor via its catalytic amino-terminal domain
	playing a role of endothelial monocyte-activating polypeptide II-like in its carboxy-terminal domain
	catalyze aminoacylation and is also procytokine activated by natural fragmentation (Yang 2007)

CELLULAR PROCESS	cell life, cell death/apoptosis
	protein, translation/synthesis
	cell migration & motility

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

a component

acetylation

INTERACTION

DNA

RNA

tRNA

small molecule	nucleotide,
	ATP

protein

interleukin-8 receptor

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

DICMTC

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS