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FLASH GENE
Symbol YARS contributors: mct/npt - updated : 29-10-2009
HGNC name tyrosyl-tRNA synthetase
HGNC id 12840
Corresponding disease
DICMTC Charcot-Marie-Tooth, dominant intermediate C
Location 1p35.1      Physical location : 33.240.839 - 33.283.633
Synonym name tyrosine tRNA ligase 1, cytoplasmic
Synonym symbol(s) YRS, YTS, tyrRS, TYRS
EC.number 6.1.1.1
DNA
TYPE functioning gene
SPECIAL FEATURE arranged in tandem
STRUCTURE 42.80 kb     13 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
13 - 3117 - 528 - Wakasugi (1999)
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivestomach   moderately
Lymphoid/Immunelymph node   highly
 spleen   moderately
Nervousbrain    
Reproductivefemale systemuteruscervix highly
Visualeye   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
Nervousperipherous   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N-terminal catalytic domain
  • a tRNA-binding domain
  • a catalytic-domain surface helix, next to the active site, recruited for interleukin-8-like cytokine signaling (Kapoor 2009)
  • a central anticodon recognition domain
  • a C-terminal EMAP II-like (endothelial monocyte-activating polypeptide II) domain (Storkebaum 2009)
  • conjugated Other
    mono polymer homomer , dimer
    HOMOLOGY
    interspecies ortholog to murine Yars
    Homologene
    FAMILY
  • class-I aminoacyl-tRNA synthetase family
  • CATEGORY enzyme , signaling cytokine
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm
    text soluble fraction
    basic FUNCTION
  • acting as a tyrosine-tRNA ligase
  • acting as an interleukin-8-like cytokine by binding to the interleukin-8 type A receptor via its catalytic amino-terminal domain
  • playing a role of endothelial monocyte-activating polypeptide II-like in its carboxy-terminal domain
  • catalyze aminoacylation and is also procytokine activated by natural fragmentation (Yang 2007)
  • CELLULAR PROCESS cell life, cell death/apoptosis
    protein, translation/synthesis
    cell migration & motility
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • acetylation
  • INTERACTION
    DNA
    RNA
  • tRNA
  • small molecule nucleotide,
  • ATP
  • protein
  • interleukin-8 receptor
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DICMTC
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS