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FLASH GENE
Symbol YARS contributors: mct/npt - updated : 29-10-2009
HGNC name tyrosyl-tRNA synthetase
HGNC id 12840
Corresponding disease
DICMTC Charcot-Marie-Tooth, dominant intermediate C
Location 1p35.1      Physical location : 33.240.839 - 33.283.633
Synonym name tyrosine tRNA ligase 1, cytoplasmic
Synonym symbol(s) YRS, YTS, tyrRS, TYRS
EC.number 6.1.1.1
DNA
TYPE functioning gene
SPECIAL FEATURE arranged in tandem
STRUCTURE 42.80 kb     13 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
DKFZp451J0118 1p34.3 taxilin MGC1203 1p36.11-p34.2 hypothetical protein MGC1203 FLJ10547 1p36.11-p34.2 hypothetical protein FLJ10547 RP4-622L5 1p36.11-p34.2 hypothetical protein RP4-622L5 EIF3S2 1p34.1 eukaryotic translation initiation factor 3, subunit 2 beta, 36kDa LOC339483 1p34.3 hypothetical protein LOC339483 MGC10820 1p34.3 hypothetical protein MGC10820 LCK 1p35.1 lymphocyte-specific protein tyrosine kinase HDAC1 1p34.3 histone deacetylase 1 MLP 1p34 MARCKS-like protein STK22C 1p34-p35 serine/threonine kinase 22C (spermiogenesis associated) FLJ10276 1p34.3 hypothetical protein FLJ10276 LOC343338 1p34.3 similar to Glyceraldehyde 3-phosphate dehydrogenase, liver (GAPDH) ZBTB8 1p34.3 zinc finger and BTB domain containing 8 ARCH 1p34.3 archease RBBP4 1p34.3 retinoblastoma binding protein 4 SYNCOILIN 1p34.3-p33 retinoblastoma binding protein 4 KIAA1522 1p34.3 KIAA1522 protein YARS 1p34.3 tyrosyl-tRNA synthetase FLJ12903 1p34.3 hypothetical protein FLJ12903 FRCP2 HPCA 1p35-p34.2 hippocalcin BCLP 1p35-p34 beta-casein-like protein FLJ90005 1p34.3 hypothetical protein FLJ90005 LOC127545 1p34.3 similar to ribosomal protein L18a; 60S ribosomal protein L18a AK2 1p34 adenylate kinase 2 ODC-p  ornithine decarboxylase-like FLJ10759 1p34.3 hypothetical protein FLJ10759 FLJ25476 1p34.3 FLJ25476 protein LOC127550 1p34.3 similar to iGb3 synthase PHC2 1p34.3 polyhomeotic-like 2 (Drosophila)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
13 - 3117 - 528 - Wakasugi (1999)
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivestomach   moderately
Lymphoid/Immunelymph node   highly
 spleen   moderately
Nervousbrain    
Reproductivefemale systemuteruscervix highly
Visualeye   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
Nervousperipherous   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N-terminal catalytic domain
  • a tRNA-binding domain
  • a catalytic-domain surface helix, next to the active site, recruited for interleukin-8-like cytokine signaling (Kapoor 2009)
  • a central anticodon recognition domain
  • a C-terminal EMAP II-like (endothelial monocyte-activating polypeptide II) domain (Storkebaum 2009)
  • conjugated Other
    mono polymer homomer , dimer
    HOMOLOGY
    interspecies ortholog to murine Yars
    Homologene
    FAMILY
  • class-I aminoacyl-tRNA synthetase family
  • CATEGORY enzyme , signaling cytokine
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm
    text soluble fraction
    basic FUNCTION
  • acting as a tyrosine-tRNA ligase
  • acting as an interleukin-8-like cytokine by binding to the interleukin-8 type A receptor via its catalytic amino-terminal domain
  • playing a role of endothelial monocyte-activating polypeptide II-like in its carboxy-terminal domain
  • catalyze aminoacylation and is also procytokine activated by natural fragmentation (Yang 2007)
  • CELLULAR PROCESS cell life, cell death/apoptosis
    protein, translation/synthesis
    cell migration & motility
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • acetylation
  • INTERACTION
    DNA
    RNA
  • tRNA
  • small molecule nucleotide,
  • ATP
  • protein
  • interleukin-8 receptor
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DICMTC
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS