Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol QTRT1 contributors: - updated : 30-08-2005
HGNC name queuine tRNA-ribosyltransferase 1 (tRNA-guanine transglycosylase)
HGNC id 23797
Location 19p13.3      Physical location : 10.812.111 - 10.824.042
Synonym name
  • tRNA-guanine transglycosylase
  • guanine insertion enzyme
  • queuine tRNA-ribosyltransferase
  • Synonym symbol(s) TGT, FP3235, TGUT
    EC.number 2.4.2.29
    DNA
    TYPE functioning gene
    STRUCTURE 11.00 kb     10 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  moderately
     pancreas exocrine   highly
    Nervousbrain   moderately
    Reproductivefemale systemuteruscervix moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervousperipherous   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer heteromer , dimer
    HOMOLOGY
    interspecies ortholog to murine Qtrt1
    ortholog to rattus qtrt1 (84 pc)
    Homologene
    FAMILY queuine tRNA-ribosyltransferase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,ribosome
    basic FUNCTION
  • exchanging the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr)
  • involved in tRNA processing
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism nucleic
    signaling
    tRNA processing
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+ (1 zinc ion per subunit)
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS