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FLASH GENE
Symbol C1QL3 contributors: mct - updated : 28-03-2022
HGNC name complement component 1, q subcomponent-like 3
HGNC id 19359
EXPRESSION
Rna function
  • C1QL2 and C1Ql3 mRNAs were potentially strongly coexpressed in the dentate gyrus
    • Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinepancreas     Homo sapiens
    Lymphoid/Immunelymph node    
    Nervousbrain   lowly Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  predominantly Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Endocrineislet cell (alpha,beta...) Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a signal peptide, a short N terminus with two highly conserved Cys residues, a collagen domain with 17 Gly-X-Y repeats
  • a signature C-terminal globular domain homologous to the immune complement C1q and whose three-dimensional structures strikingly resemble that of TNF
    • HOMOLOGY
    Homologene
    FAMILY C1q/TNF family
    CATEGORY signaling
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • may play diverse roles by forming homomeric and heteromeric complexes in the central nervous system
  • C1QL1, C1QL2, C1QL3, C1QL4 proteins are secreted signaling molecules that bind to ADGRB3 and act, at least in part, to regulate synapse formation and/or maintenance
  • adipokine that promotes glucose uptake in adipocytes, myotubes, and hepatocytes via activation of the AMPK signaling pathway
  • also ameliorates lipid-induced insulin resistance in hepatocytes through suppression of the SAPK/JNK stress signaling that impairs the insulin signaling pathway
  • important role in glucose homeostasis
  • C1QL3 is likely a signaling protein essential for subsets of synaptic projections and the behaviors controlled by these projections
  • C1QL2 and C1QL3, released from mossy fibers, determine the synaptic localization of postsynaptic kainate receptors in the hippocampus
  • C1QL3 also regulates the formation of synapses between the basolateral amygdala and the prefrontal cortex
  • is a putative contributor to reduced insulin secretion in obesity, and is linked likely to an increased susceptibility to type 2 diabetes
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • forms heteromeric complexes with a closely related family member, C1QL2
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • C1Ql2 and C1QL3, produced by mossy fiber (MFs), serve as extracellular organizers to recruit functional postsynaptic kainate-type glutamate receptors (KARs) complexes to the CA3 pyramidal neurons
  • ADGRB3 mediates likely the inhibitory effects of C1QL3 on insulin secretion from pancreatic beta-cells
  • C1QL3 mediates a novel cell-cell adhesion complex involving ADGRB3 and two neuronal pentraxins, NPTX1 and NPTXR
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    diabetetype 2 
    therapeutic potential of C1QL3 against diabetic vasculopathy
    ANIMAL & CELL MODELS
  • C1ql3-deficient mice exhibited fewer excitatory synapses and diverse behavioral abnormalities, including marked impairments in fear memories.