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FLASH GENE

Symbol

C1QL3

contributors: mct - updated : 28-03-2022

HGNC name	complement component 1, q subcomponent-like 3
HGNC id	19359

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001010908 2 - 2493 NP_001010908 - 255 - 2005 15953544

EXPRESSION

Rna function	C1QL2 and C1Ql3 mRNAs were potentially strongly coexpressed in the dentate gyrus
Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine pancreas         Homo sapiens Lymphoid/Immune lymph node         Nervous brain       lowly Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective adipose     predominantly Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Endocrine islet cell (alpha,beta...) Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a signal peptide, a short N terminus with two highly conserved Cys residues, a collagen domain with 17 Gly-X-Y repeats
	a signature C-terminal globular domain homologous to the immune complement C1q and whose three-dimensional structures strikingly resemble that of TNF

HOMOLOGY

Homologene

FAMILY

C1q/TNF family

CATEGORY

signaling

SUBCELLULAR LOCALIZATION

extracellular

basic FUNCTION	may play diverse roles by forming homomeric and heteromeric complexes in the central nervous system
	C1QL1, C1QL2, C1QL3, C1QL4 proteins are secreted signaling molecules that bind to ADGRB3 and act, at least in part, to regulate synapse formation and/or maintenance
	adipokine that promotes glucose uptake in adipocytes, myotubes, and hepatocytes via activation of the AMPK signaling pathway
	also ameliorates lipid-induced insulin resistance in hepatocytes through suppression of the SAPK/JNK stress signaling that impairs the insulin signaling pathway
	important role in glucose homeostasis
	C1QL3 is likely a signaling protein essential for subsets of synaptic projections and the behaviors controlled by these projections
	C1QL2 and C1QL3, released from mossy fibers, determine the synaptic localization of postsynaptic kainate receptors in the hippocampus
	C1QL3 also regulates the formation of synapses between the basolateral amygdala and the prefrontal cortex
	is a putative contributor to reduced insulin secretion in obesity, and is linked likely to an increased susceptibility to type 2 diabetes

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

forms heteromeric complexes with a closely related family member, C1QL2

INTERACTION

DNA

RNA

small molecule

protein	C1Ql2 and C1QL3, produced by mossy fiber (MFs), serve as extracellular organizers to recruit functional postsynaptic kainate-type glutamate receptors (KARs) complexes to the CA3 pyramidal neurons
	ADGRB3 mediates likely the inhibitory effects of C1QL3 on insulin secretion from pancreatic beta-cells
	C1QL3 mediates a novel cell-cell adhesion complex involving ADGRB3 and two neuronal pentraxins, NPTX1 and NPTXR

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed diabete type 2   therapeutic potential of C1QL3 against diabetic vasculopathy

ANIMAL & CELL MODELS

C1ql3-deficient mice exhibited fewer excitatory synapses and diverse behavioral abnormalities, including marked impairments in fear memories.