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FLASH GENE
Symbol C1QL2 contributors: mct - updated : 31-03-2022
HGNC name complement component 1, q subcomponent-like 2
HGNC id 24181
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a signature C-terminal globular domain homologous to the immune complement C1q and whose three-dimensional structures strikingly resemble that of TNF
    • HOMOLOGY
    Homologene
    FAMILY
  • C1q/TNF family
    • CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • secreted multimeric protein that interact with cell surface receptors
  • may play diverse roles by forming homomeric and heteromeric complexes in the central nervous system
  • C1QL1, C1QL2, C1QL3, C1QL4 proteins are secreted signaling molecules that bind to ADGRB3 and act, at least in part, to regulate synapse formation and/or maintenance
  • C1QL2 and C1QL3, released from mossy fibers, determine the synaptic localization of postsynaptic kainate receptors in the hippocampus
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component forms heteromeric complexes with a closely related family member, C1QL3
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • C1Ql2 and C1QL3, produced by mossy fiber (MFs), serve as extracellular organizers to recruit functional postsynaptic kainate-type glutamate receptors (KARs) complexes to the CA3 pyramidal neurons
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS