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FLASH GENE

Symbol

C1QL2

contributors: mct - updated : 31-03-2022

HGNC name	complement component 1, q subcomponent-like 2
HGNC id	24181

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_182528 2 - 2049 NP_872334 - 287 - 2008 18783346

EXPRESSION

Rna function	C1QL2 and C1Ql3 mRNAs were potentially strongly coexpressed in the dentate gyrus
Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain         Reproductive female system placenta     predominantly Homo sapiens Visual eye       predominantly Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a signature C-terminal globular domain homologous to the immune complement C1q and whose three-dimensional structures strikingly resemble that of TNF

HOMOLOGY

Homologene

FAMILY

C1q/TNF family

CATEGORY

immunity/defense

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,cytoplasm,organelle,endoplasmic reticulum

basic FUNCTION	secreted multimeric protein that interact with cell surface receptors
	may play diverse roles by forming homomeric and heteromeric complexes in the central nervous system
	C1QL1, C1QL2, C1QL3, C1QL4 proteins are secreted signaling molecules that bind to ADGRB3 and act, at least in part, to regulate synapse formation and/or maintenance
	C1QL2 and C1QL3, released from mossy fibers, determine the synaptic localization of postsynaptic kainate receptors in the hippocampus

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

forms heteromeric complexes with a closely related family member, C1QL3

INTERACTION

DNA

RNA

small molecule

protein

C1Ql2 and C1QL3, produced by mossy fiber (MFs), serve as extracellular organizers to recruit functional postsynaptic kainate-type glutamate receptors (KARs) complexes to the CA3 pyramidal neurons

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS