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FLASH GENE
Symbol C1QL4 contributors: mct - updated : 28-03-2022
HGNC name complement component 1, q subcomponent-like 4
HGNC id 31416
DNA
TYPE functioning gene
STRUCTURE 4.79 kb     2 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 2073 - 238 - 2019 30608882
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain     Homo sapiens
Reproductivefemale systemovary   
 female systemuterus   
 male systemtestis    Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose    Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
a C1Q domain
HOMOLOGY
Homologene
FAMILY C1q/TNF family
CATEGORY unknown/unspecified
SUBCELLULAR LOCALIZATION extracellular
    intracellular
intracellular,cytoplasm,organelle,endoplasmic reticulum
basic FUNCTION
  • C1QL1, C1QL2, C1QL3, C1QL4 proteins are secreted signaling molecules that bind to ADGRB3 and act, at least in part, to regulate synapse formation and/or maintenance
  • CQL1/Ctrp14 and C1QL4/Ctrp11 stimulate the new blood vessel growth by activation of ERK1/2 signal pathway
  • C1QL4 served as a novel acute regulator of testosterone secretion, and ADGRB3 functioned as a new receptor that is involved in steroidogenesis in Leydig cells
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ADGRB3 is spatiotemporally regulated by C1QL4 and STAB2 during myoblast fusion
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS