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FLASH GENE

Symbol

CBLN4

contributors: mct - updated : 21-09-2016

HGNC name	cerebellin 4 precursor
HGNC id	16231

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	20q13.31      Physical location : 54.572.496 - 54.580.012
Synonym name	cerebellin precursor-like 1
Synonym symbol(s)	CBLNL1, UNQ718/PRO1382

DNA

TYPE	functioning gene
STRUCTURE	7.52 kb     3 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_080617 3 - 2573 - 201 - 2007 17331201

EXPRESSION

Rna function	CBLN1, CBLN2 and CBLN4 mRNAs are expressed in distinct brain regions, but these regions are partly overlapping
	mRNAs of CBLN(1 to 4) expressed in the human adrenal gland (
Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain           brain forebrain       Homo sapiens Reproductive male system testis

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a C1Q domain
	a signal peptide
	two N-linked glycosylation sites, one at the N-terminus is in a region implicated in NRXN binding and the second is in the C1q domain, a region involved in GRID2 binding

isoforms

Precursor

HOMOLOGY

Homologene

FAMILY

cerebellin family

CATEGORY

immunity/defense

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,cytoplasm
text	synapses

basic FUNCTION	having a neuromodulatory function
	CBLN1, CBLN2 and CBLN4 may serve as transneuronal regulators of synaptic functions in various brain regions
	may generally serve as a new class of transneuronal regulators of synapse development and synaptic plasticity in various brain regions
	with CBLN2 and CBLN1, exert synaptogenic activities in cortical neurons by differentially interacting with NRXN variants containing S4

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	potential interaction with both SRY and SOX9 (SRY and SOX9 may contribute to the male-specific upregulation of CBLN4 in the developing testis)
	NRXNs may mediate synapse formation in the forebrain by interacting with CBLN1, CBLN2 and CBLN4

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS