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FLASH GENE

Symbol

PARP16

contributors: mct - updated : 21-03-2016

HGNC name	poly (ADP-ribose) polymerase family, member 16
HGNC id	26040

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	15q22.31      Physical location : 65.550.437 - 65.579.018
Synonym symbol(s)	C15orf30, FLJ20509, FLJ25281, ARTD15, pART15
EC.number	2.4.2.30

DNA

TYPE	functioning gene
STRUCTURE	29.00 kb     6 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_017851 - - 2551 NP_060321 - 323 - 2012 22701565

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune thymus       highly Urinary kidney       highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a transferase domain likely regulated by effector binding to the adjacent helical domain

secondary structure

mono(ADP-ribose) transferase with a novel alpha-helical domain that interacts with a catalytic domain loop

HOMOLOGY

Homologene

FAMILY

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum
	intracellular,nucleus

basic FUNCTION	displays auto-mono(ADP-ribosylation) activity and is affected by canonical poly(ADP-ribose) polymerase inhibitors
	has ADP-ribose transferase activity, is capable of automodification, and can be inhibited by canonical PARP inhibitors
	mono-ADP-ribosyltransferase with a new intracellular location, as it is associated with the endoplasmic reticulum
	appears to have a role in nucleocytoplasmic shuttling

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	binds to canonical PARP inhibitors
	tail-anchored ER transmembrane protein required for activation of the functionally related ER stress sensors EIF2AK3 and ERN1
	ERN1 signaling is quite context-specific on account of many adaptor and modulator proteins that directly interact with it, including heat shock proteins (HSPs), RNF13, PARP16, TMBIM6

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS