Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol PARP14 contributors: mct - updated : 30-08-2011
HGNC name poly (ADP-ribose) polymerase family, member 14
HGNC id 29232
Location 3q21.1      Physical location : 122.399.671 - 122.449.686
Synonym name
  • B-aggressive lymphoma 2
    • Synonym symbol(s) BAL2, KIAA1268, PARP-14, pART8
    EC.number 2.4.2.30
    DNA
    TYPE functioning gene
    STRUCTURE 50.02 kb     17 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    17 - 7713 - 1801 - 2004 15273990
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly
     mouthtongue  highly
    Lymphoid/Immunethymus   moderately Homo sapiens
    Reproductivefemale systemuterus  highly
    Respiratoryrespiratory tractlarynx   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal macro domains
  • putative C-terminal PARP active sites
    • HOMOLOGY
    Homologene
    FAMILY BAL family of macrodomain proteins
    CATEGORY immunity/defense , transcription factor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • with PARP9, are macro domain containing poly(ADP-ribose) polymerases involved in transcriptional regulation in response to immunoregulatory cytokines
  • enzymatic activity of PARP14 is required for its enhancement of STAT6-mediated transcription
  • plays a fundamental role mediating protection against apoptosis in IL4-treated B cells, including that after DNA damage, and mediates IL4 effects on the levels of gene products that regulate cell survival, proliferation, and lymphomagenesis
  • mediates regulation of gene expression and lymphocyte physiology by IL4 and has a function distinct from PARP1
  • in the presence of IL4, PARP14 promotes efficient binding of STAT6 to its target gene
  • functions as a transcriptional switch for STAT6-dependent gene induction
  • PARP14-dependent capacity to increase cellular metabolic rates may be an important determinant of lymphoma pathobiology
  • coactivator of STAT6 at some target genes
  • accelerates lymphoma and regulates cellular energy metabolism to promote B-cell survival
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding partner of the IL4-induced transcription factor STAT6
  • mediates IL4–enhanced mitochondrial activity in B cells
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       loss of function
    delayed B lymphomagenesis and reversed the block to B-cell maturation driven by the Myc oncogene
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancermetastases 
    new therapeutic target for inhibition of PGI/AMF inducing tumor cell migration and invasion during metastasis
    allergyasthm 
    targeting PARP14 activity may be a potential therapy for asthma and allergy
    ANIMAL & CELL MODELS