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FLASH GENE

Symbol

PARP10

contributors: - updated : 13-12-2006

HGNC name	poly (ADP-ribose) polymerase family, member 10
HGNC id	25895

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	8q24.3      Physical location : 145.051.320 - 145.060.635
Synonym symbol(s)	FLJ14464

DNA

TYPE	functioning gene
SPECIAL FEATURE	opposite orientation
text	head-to-tail arrangement with PLEC1
STRUCTURE	9.00 kb     11 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive mouth       highly   salivary gland       highly Lymphoid/Immune spleen       highly   thymus       highly Reproductive female system uterus cervix     Respiratory respiratory tract trachea     highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a poly(ADP-ribose) polymerase domain, capable of ADP-ribosylating PARP-10 itself and core histones, but neither Myc nor Max
	an RNA recognition motif and two ubiquitin interaction motifs
	domains with homology to RNA recognition motifs and to poly(ADP-ribose) polymerases (PARP)

HOMOLOGY

interspecies

homolog to murine Parp10

Homologene

FAMILY

PARP family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus,nucleolus
text	localized to the nuclear and cytoplasmic compartments that is controlled at least in part by a Leu-rich nuclear export sequence (NES)

basic FUNCTION	Myc-interacting protein with poly(ADP-ribose) polymerase activity, involved in the control of cell proliferation
	functioning in cell proliferation and may serve as a marker for proliferating cells
	only nucleolar form acquires CDK-dependent phosphorylation through late-G1 to S phase, and from prometaphase to cytokinesis in the nucleolar organizing regions

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

interacts with Myc

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS