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FLASH GENE

Symbol

SELENOI

contributors: mct/ - updated : 17-11-2021

HGNC name	ethanolaminephosphotransferase 1 (CDP-ethanolamine-specific)
HGNC id	29361

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	49.81 kb     10 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_033505 10 - 8066 NP_277040 45 397 - 2007

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain hindbrain cerebellum   highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Nervous peripherous

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	CDP-alcohol phosphatidyltransferase signature
	a common motif conserved in phospholipid synthases

HOMOLOGY

Homologene

FAMILY	selenoproteins family
	CDP-alcohol phosphatidyltransferase class-I family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum
	intracellular,cytoplasm,organelle,Golgi
text	integral membrane protein

basic FUNCTION	involved in the biosynthesis of phosphatidylethanolamine via the Kennedy pathway
	indispensable role of SELENOI in the myelination process and neurodevelopment, and in the maintenance of normal homeostasis of ether-linked phospholipids
	enzyme participating in two metabolic pathways for the synthesis of phosphatidylethanolamine (PE) and plasmenyl PE

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

upregulated ethanolamine phospholipid synthesis via SELENOI is required for effective metabolic reprogramming during T cell activation

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

SPG81

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional       loss of function lowers but does not completely diminish de novo synthesis of phosphatidylethanolamine (PE) and plasmenyl PE during T cell activation

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS