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Symbol SELENOI contributors: mct/ - updated : 17-11-2021
HGNC name ethanolaminephosphotransferase 1 (CDP-ethanolamine-specific)
HGNC id 29361
Corresponding disease
SPG81 spastic paraplegia 81
Location 2p23.3      Physical location : -
Synonym name
  • selenoprotein I
  • ethanolaminephosphotransferase 1
  • Synonym symbol(s) KIAA1724, SELI, SEPI, EPT1
    EC.number 2.7.8.1
    DNA
    TYPE functioning gene
    STRUCTURE 49.81 kb     10 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 8066 45 397 - 2007
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrainhindbraincerebellum highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervousperipherous   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • CDP-alcohol phosphatidyltransferase signature
  • a common motif conserved in phospholipid synthases
  • HOMOLOGY
    Homologene
    FAMILY
  • selenoproteins family
  • CDP-alcohol phosphatidyltransferase class-I family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    text integral membrane protein
    basic FUNCTION
  • involved in the biosynthesis of phosphatidylethanolamine via the Kennedy pathway
  • indispensable role of SELENOI in the myelination process and neurodevelopment, and in the maintenance of normal homeostasis of ether-linked phospholipids
  • enzyme participating in two metabolic pathways for the synthesis of phosphatidylethanolamine (PE) and plasmenyl PE
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • upregulated ethanolamine phospholipid synthesis via SELENOI is required for effective metabolic reprogramming during T cell activation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SPG81
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    lowers but does not completely diminish de novo synthesis of phosphatidylethanolamine (PE) and plasmenyl PE during T cell activation
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS