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FLASH GENE

Symbol

IGF2BP1

contributors: mct/pgu - updated : 09-07-2013

HGNC name	insulin-like growth factor 2 mRNA binding protein 1
HGNC id	28866

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	58.73 kb     15 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001160423 - - 8352 NP_001153895 - 438 - 1999 9891060 isoform 2 NM_006546 15 - 8769 NP_006537 - 577 - 1999 9891060 isoform 1

EXPRESSION

Type

widely

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine small intestine         liver       moderately Lymphoid/Immune thymus       highly Reproductive female system ovary         female system placenta         male system testis         male system prostate       Respiratory lung           respiratory tract trachea       Urinary kidney         Visual eye       moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Nervous peripherous

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic progenitor cell Homo sapiens Lymphoid/Immune lymphocyte Homo sapiens Muscular myoblast

cell lineage
cell lines
fluid/secretion	lymph

at STAGE

physiological period

fetal

Text

liver

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	four K homology domains
	two RNA recognition motifs

conjugated

PhosphoP

mono polymer

homomer , heteromer , dimer

HOMOLOGY

interspecies	homolog to murine Igf2bp1 (99.3pc)
	homolog to rattus Igf2bp1 (99.7pc)

Homologene

FAMILY	IGF-II mRNA-binding protein (IMP) family
	RRM IMP/VICKZ family

CATEGORY

regulatory , RNA associated

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,cytoplasm,cytoskeleton,microtubule
	intracellular,nucleus
text	associated with microtubules and polysomes

basic FUNCTION	regulating IGF2 translation
	implicated in subcytoplasmic localization of mRNAs during embryogenesis
	functions by binding to the mRNA of certain genes, including insulin-like growth factor 2, beta actin, and beta-transducin repeat-containing protein and regulating their translation
	is essential for the induction of both BTRCP1 and c-Myc by beta-catenin signaling in colorectal cancer cells
	involved in the upregulation of BTRCP1, in the activation of dimeric transcription factor by NF-kappa B and in the suppression of apoptosis in these cancers
	may act as a regulator of mRNA transport to activated synpases in response to synaptic activity
	acting as a HIV-1 retrovirus resctriction factor that reduces HIV-1 assembly by inhibiting viral RNA packaging, assembly and processing of HIV-1 GAG protein on cellular membranes
	oncogenic factor involved in promoting elevated proliferation by stabilizing the c-myc mRNA in ovarian carcinoma cells
	is likely to play important roles in lung cancer development and progression
	implicated in RNA regulatory processes such as intracellular RNA localization, RNA stability, and translational control
	may play a role in cancer cell migration
	play an important role in colorectal catrcinoma metastasis by shuttling requisite RNAs to the lamellipodia of migrating cells
	controls spatially restricted BETA-actin (ACTB) mRNA translation and modulates growth cone guidance
	promotes the velocity and directionality of tumor-derived cell migration by determining the cytoplasmic fate of two novel target mRNAs: MAPK4 and PTEN
	promotes the velocity and persistence of tumor cell migration by controlling the expression of signaling proteins

CELLULAR PROCESS	nucleotide, transcription, regulation
	protein, translation regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	component of the coding region determinant (CRD)-mediated complex
	identified in a HCV IRES-mediated translation complex
	identified in a mRNP complex
	in complex with four proteins promotes CRD-mediated c-myc mRNA stabilization

INTERACTION

DNA

RNA	binding to the 5' UTR of the insulin-like growth factor 2 (IGF2) mRNA
	binding to the coding region of BTRCP1 mRNA and stabilizing it, preventing its degradation by attenuating its miRNA-183-dependent interaction with Ago2 ,
	interacting with both hepatitis C virus 5'UTR and 3'UTR, recruiting EIF3 and enhancing HCV translation

small molecule

protein	heterodimerizing with IGF2BP3
	interacting with HIV-1 GAG
	interacting with DHX9, ELAVL2, HNRNPA2B1, HNRNPC, HNRNPH1, HNRNPU, IGF2BP2, ILF2, PABPC1, YBX1, FMR1, ELAVL4
	specific interaction of KIF11 with IGF2BP1 regulates the transport of ACTB mRNA and cell motility

cell & other

REGULATION

inhibited by

tumor-suppressive lipooxygenases, resulting in inhibition of prostate carcinoma cell proliferation

Other	upregulated in response to beta-catenin activation
	beta catenin binds to IGF2BP1 promoter and activates its expression in breast cancer cells. Feedback loop regulation, IGF2BP1 associating with beta catenin mRNA and increasing its stability

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral         amplified in breast cancer tumoral     --over   overexpressed in primary malignant melanomas tumoral     --over   observed preferentially in high-grade and high-stage cases and significant prognostic indicator for reduced recurrence-free and overall survival tumoral     --other   aberrant expression in diffuse large B-cell

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	prognostic biomarker for lung cancer
Therapy target
	System Type Disorder Pubmed cancer skin   knockdown of IGF2BP1 inhibits NF-KappaB activity, induces apoptosis and suppresses proliferation and tumorigenic properties of melanoma cells cancer lung   promising therapeutic target for lung cancer

ANIMAL & CELL MODELS