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FLASH GENE
Symbol GSTT2 contributors: KTN/npt - updated : 21/11/2008
HGNC name glutathione S-transferase theta 2
HGNC id 4642
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a GST N-terminal domain
  • a GST C-terminal domain
    • mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to chimpanzee GSTT2B (98.8 pc)
    homolog to rattus Gstt2 (78.3 pc)
    homolog to murine Gstt2 (77.4 pc)
    Homologene
    FAMILY
  • GST superfamily
  • theta family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles
  • playing an important role in human carcinogenesis
  • acting as a sulfatase
  • participating in detoxification and defense mechanisms against toxic carcinogens and other compounds
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS