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FLASH GENE
Symbol GSTT2 contributors: KTN/npt - updated : 21/11/2008
HGNC name glutathione S-transferase theta 2
HGNC id 4642
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   moderately
Digestivesalivary gland   predominantly
Endocrineadrenal gland   highly
Reproductivefemale systemuteruscervix moderately
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a GST N-terminal domain
  • a GST C-terminal domain
    • mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to chimpanzee GSTT2B (98.8 pc)
    homolog to rattus Gstt2 (78.3 pc)
    homolog to murine Gstt2 (77.4 pc)
    Homologene
    FAMILY
  • GST superfamily
  • theta family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles
  • playing an important role in human carcinogenesis
  • acting as a sulfatase
  • participating in detoxification and defense mechanisms against toxic carcinogens and other compounds
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS