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Symbol RXFP3 contributors: npt/mct - updated : 01-12-2014
HGNC name relaxin/insulin-like family peptide receptor 3
HGNC id 24883
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminus and extracellular loop 2 domains of RXFP3 and RXFP4 are involved in ligand binding while TM2, 3, and 5 are critical for receptor activation
  • seven transmembrane domains
  • two putative N-glycosylation sites
  • C-terminal SER or THR residues may be phosphorylated
    • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine Rln3r1
    Homologene
    FAMILY
  • G protein coupled receptor 1 family
    • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • binding of the ligand relaxin 3 inhibits cAMP accumulation
  • receptor for angiotensin II, mediating its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal , signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to relaxin 3
  • RLN3 is thought to act in the brain via the RXFP3 receptor, although the RXFP1 receptor may also play a role
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS