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FLASH GENE
Symbol RXFP3 contributors: npt/mct - updated : 01-12-2014
HGNC name relaxin/insulin-like family peptide receptor 3
HGNC id 24883
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivesalivary gland   lowly
Endocrineadrenal gland   highly
Nervousbrainbasal nucleicaudate nucleus predominantly
 brainmidbrainsubstantia nigra predominantly
 brainlimbic systemhippocampus predominantly
 braindiencephalonhypothalamus predominantly Homo sapiens
 brainbasal nucleicorpus callosum predominantly
Reproductivefemale systembreastmammary gland lowly
 male systemtestis  lowly Homo sapiens
 male systemprostate  highly Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminus and extracellular loop 2 domains of RXFP3 and RXFP4 are involved in ligand binding while TM2, 3, and 5 are critical for receptor activation
  • seven transmembrane domains
  • two putative N-glycosylation sites
  • C-terminal SER or THR residues may be phosphorylated
  • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine Rln3r1
    Homologene
    FAMILY
  • G protein coupled receptor 1 family
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • binding of the ligand relaxin 3 inhibits cAMP accumulation
  • receptor for angiotensin II, mediating its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal , signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to relaxin 3
  • RLN3 is thought to act in the brain via the RXFP3 receptor, although the RXFP1 receptor may also play a role
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS