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FLASH GENE

Symbol

RXFP3

contributors: npt/mct - updated : 01-12-2014

HGNC name	relaxin/insulin-like family peptide receptor 3
HGNC id	24883

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	5p13.2      Physical location : 33.936.490 - 33.939.023
Synonym name	somatostatin and angiotensin-like peptide receptor
	G-protein coupled receptor SALPR
	relaxin 3 receptor 1
	relaxin family peptide receptor 3
Synonym symbol(s)	SALPR, GPCR135, RLN3R1, RXFPR3, MGC1419982, MGC142000

DNA

TYPE	functioning gene
STRUCTURE	1.85 kb     1 Exon(s)    1 Copie(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_016568 1 - 2533 NP_057652 - 469 - -

EXPRESSION

Type

widely

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive salivary gland       lowly Endocrine adrenal gland       highly Nervous brain basal nuclei caudate nucleus   predominantly   brain midbrain substantia nigra   predominantly   brain limbic system hippocampus   predominantly   brain diencephalon hypothalamus   predominantly Homo sapiens   brain basal nuclei corpus callosum   predominantly Reproductive female system breast mammary gland   lowly   male system testis     lowly Homo sapiens   male system prostate     highly Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N-terminus and extracellular loop 2 domains of RXFP3 and RXFP4 are involved in ligand binding while TM2, 3, and 5 are critical for receptor activation
	seven transmembrane domains
	two putative N-glycosylation sites
	C-terminal SER or THR residues may be phosphorylated

conjugated

GlycoP

HOMOLOGY

interspecies

ortholog to murine Rln3r1

Homologene

FAMILY

G protein coupled receptor 1 family

CATEGORY

receptor membrane G

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	binding of the ligand relaxin 3 inhibits cAMP accumulation
	receptor for angiotensin II, mediating its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

hormonal , signal transduction

a component

INTERACTION

DNA

RNA

small molecule

protein	binding to relaxin 3
	RLN3 is thought to act in the brain via the RXFP3 receptor, although the RXFP1 receptor may also play a role

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS