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FLASH GENE
Symbol GPC1 contributors: mct - updated : 14-10-2011
HGNC name glypican 1
HGNC id 4449
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • thirteen cysteines at conserved position
    • HOMOLOGY
    interspecies homolog to murine Gpc1
    Homologene
    FAMILY glypican family
    CATEGORY adhesion
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    text anchored to the membrane via a glycosyl phosphatidylinositol anchor
    basic FUNCTION
  • involved in cell adhesion
  • cell growth histogenesis of nervous central system
  • cell surface heparan sulfate proteoglycan that acts as a co-receptor for heparin-binding growth factors as well as for members of the TGF-beta family
  • playing plays a role in pancreatic cancer by regulating growth factor responsiveness
  • can regulate Endothelial cells cell cycle progression at least partially by modulating APC/C-mediated degradation of mitotic cyclins and securin
  • playing a possible role in the pathogenesis of Alzheimer disease
  • controls brain size through regulation of fibroblast growth factor signaling in early neurogenesis
  • potential role of glypican-1 and possibly other members of the glypican family in prion metabolism
  • acts as a positive regulator of muscle differentiation by sequestering FGF2 in lipid rafts and preventing its binding and dependent signaling
  • appropriate levels of GPC1 are essential for proper regulation of canonical Wnt signaling during differentiation and organization of trigeminal placodal cells into ganglia
    • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component (heparan sulfate) proteoglycan constituent of integral membrane
    INTERACTION
    DNA
    RNA
    small molecule
    protein receptor of SLIT1 and SLIT3
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DEL2Q37
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in pancreatic cancer cell
    tumoral     --over  
    in astrocytoma and oligodendroglioma samples compared with nonneoplastic gliosis
    Susceptibility
    Variant & Polymorphism
    Candidate gene for brachymetaphalangism and/or obesity in the del2q37 syndrome
    Marker
    Therapy target
    ANIMAL & CELL MODELS