Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

GPC1

contributors: mct - updated : 14-10-2011

HGNC name	glypican 1
HGNC id	4449

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_002081 9 - 3686 - 558 - 1999 10364234

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive esophagus       highly   salivary gland       highly Reproductive female system uterus cervix   highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone       Muscular striatum skeletal   highly

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text	skeletal system

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

thirteen cysteines at conserved position

HOMOLOGY

interspecies

homolog to murine Gpc1

Homologene

FAMILY

glypican family

CATEGORY

adhesion

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane
text	anchored to the membrane via a glycosyl phosphatidylinositol anchor

basic FUNCTION	involved in cell adhesion
	cell growth histogenesis of nervous central system
	cell surface heparan sulfate proteoglycan that acts as a co-receptor for heparin-binding growth factors as well as for members of the TGF-beta family
	playing plays a role in pancreatic cancer by regulating growth factor responsiveness
	can regulate Endothelial cells cell cycle progression at least partially by modulating APC/C-mediated degradation of mitotic cyclins and securin
	playing a possible role in the pathogenesis of Alzheimer disease
	controls brain size through regulation of fibroblast growth factor signaling in early neurogenesis
	potential role of glypican-1 and possibly other members of the glypican family in prion metabolism
	acts as a positive regulator of muscle differentiation by sequestering FGF2 in lipid rafts and preventing its binding and dependent signaling
	appropriate levels of GPC1 are essential for proper regulation of canonical Wnt signaling during differentiation and organization of trigeminal placodal cells into ganglia

CELLULAR PROCESS

cell communication

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

(heparan sulfate) proteoglycan constituent of integral membrane

INTERACTION

DNA

RNA

small molecule

protein

receptor of SLIT1 and SLIT3

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

DEL2Q37

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in pancreatic cancer cell tumoral     --over   in astrocytoma and oligodendroglioma samples compared with nonneoplastic gliosis

Susceptibility

Variant & Polymorphism

Candidate gene	for brachymetaphalangism and/or obesity in the del2q37 syndrome
Marker
Therapy target

ANIMAL & CELL MODELS