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FLASH GENE
Symbol GPC1 contributors: mct - updated : 14-10-2011
HGNC name glypican 1
HGNC id 4449
DNA
TYPE functioning gene
STRUCTURE 32.38 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 3686 - 558 - 1999 10364234
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   highly
 salivary gland   highly
Reproductivefemale systemuteruscervix highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
Muscularstriatumskeletal highly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text skeletal system
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • thirteen cysteines at conserved position
    • HOMOLOGY
    interspecies homolog to murine Gpc1
    Homologene
    FAMILY glypican family
    CATEGORY adhesion
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    text anchored to the membrane via a glycosyl phosphatidylinositol anchor
    basic FUNCTION
  • involved in cell adhesion
  • cell growth histogenesis of nervous central system
  • cell surface heparan sulfate proteoglycan that acts as a co-receptor for heparin-binding growth factors as well as for members of the TGF-beta family
  • playing plays a role in pancreatic cancer by regulating growth factor responsiveness
  • can regulate Endothelial cells cell cycle progression at least partially by modulating APC/C-mediated degradation of mitotic cyclins and securin
  • playing a possible role in the pathogenesis of Alzheimer disease
  • controls brain size through regulation of fibroblast growth factor signaling in early neurogenesis
  • potential role of glypican-1 and possibly other members of the glypican family in prion metabolism
  • acts as a positive regulator of muscle differentiation by sequestering FGF2 in lipid rafts and preventing its binding and dependent signaling
  • appropriate levels of GPC1 are essential for proper regulation of canonical Wnt signaling during differentiation and organization of trigeminal placodal cells into ganglia
    • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component (heparan sulfate) proteoglycan constituent of integral membrane
    INTERACTION
    DNA
    RNA
    small molecule
    protein receptor of SLIT1 and SLIT3
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DEL2Q37
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in pancreatic cancer cell
    tumoral     --over  
    in astrocytoma and oligodendroglioma samples compared with nonneoplastic gliosis
    Susceptibility
    Variant & Polymorphism
    Candidate gene for brachymetaphalangism and/or obesity in the del2q37 syndrome
    Marker
    Therapy target
    ANIMAL & CELL MODELS