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FLASH GENE

Symbol

METTL11A

contributors: mct - updated : 02-05-2018

HGNC name	methyltransferase like 11A
HGNC id	23373

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	9q34.11      Physical location : 132.388.434 - 132.397.879
Synonym name	N-terminal RCC1 methyltransferase
	X-Pro-Lys N-terminal protein methyltransferase 1A
	alpha N-terminal protein methyltransferase 1A
	chromosome 9 open reading frame 32
Synonym symbol(s)	AD-003, C9orf32, NRMT, NTM1A
EC.number	2.1.1.-

DNA

TYPE	functioning gene
STRUCTURE	9.45 kb     4 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_014064 4 - 1007 NP_054783 25 223 - 2010 20668449

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine small intestine       Skin/Tegument skin

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone       Nervous peripherous

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a Rossman-like alpha/beta fold
	lacks a SET domain

HOMOLOGY

Homologene

FAMILY	methyltransferase superfamily
	methyltransferase 11 family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus

basic FUNCTION

acting as a S-adenosylmethionine-dependent methyltransferase

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	predominant alpha-N-methyltransferase for RCC1
	is a major enzyme required for the CENPB methylation

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional         silencing METTL11A reduces RCC1 association with chromatin, and increases frequency of mitotic defects

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS