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FLASH GENE
Symbol MGAT5B contributors: mct - updated : 22-08-2012
HGNC name mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isoenzyme B
HGNC id 24140
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
intraspecies paralog to MGAT5
Homologene
FAMILY
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,organelle,Golgi
text type II membrane protein
basic FUNCTION
  • DNA-dependent RNA polymerase catalyzing the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
  • responsible for the synthesis of a unique oligosaccharide structure in the brain
  • with POMGNT1, enzymes involved in the O-mannosyl glycosylation pathway, play an active role in modulating integrin and laminin-dependent adhesion and migration of human neuronal cells
  • its expression enhances neurite outgrowth on laminin.
  • synthesize both GlcNAcbeta1,6Man branched N- and O-glycans
  • intrinsic and specific role in the nervous system
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MGAT5B-mediated glycosylation of PTPRZ1 promotes galectin-1 binding and PTPRZ1 levels of retention on the cell surface
  • interacting with CTCF (transcription of MGAT5B is mediated by the binding of CTCF)
  • ENPP3 is a inhibitor for MGAT5B, which catalyzes the hydrolysis of the nucleotide sugar donor substrate UDP-GlcNAc
    • cell & other
    REGULATION
    activated by CTCF and NEUROD1 (CTCF and NEUROD1 involved in the activation of MGAT5B expression)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS