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FLASH GENE
Symbol MGAT5B contributors: mct - updated : 22-08-2012
HGNC name mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isoenzyme B
HGNC id 24140
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain     Homo sapiens
Reproductivemale systemtestis    Homo sapiens
Visualeye    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervouscentral    Homo sapiens
Nervousperipherous    Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
intraspecies paralog to MGAT5
Homologene
FAMILY
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,organelle,Golgi
text type II membrane protein
basic FUNCTION
  • DNA-dependent RNA polymerase catalyzing the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
  • responsible for the synthesis of a unique oligosaccharide structure in the brain
  • with POMGNT1, enzymes involved in the O-mannosyl glycosylation pathway, play an active role in modulating integrin and laminin-dependent adhesion and migration of human neuronal cells
  • its expression enhances neurite outgrowth on laminin.
  • synthesize both GlcNAcbeta1,6Man branched N- and O-glycans
  • intrinsic and specific role in the nervous system
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MGAT5B-mediated glycosylation of PTPRZ1 promotes galectin-1 binding and PTPRZ1 levels of retention on the cell surface
  • interacting with CTCF (transcription of MGAT5B is mediated by the binding of CTCF)
  • ENPP3 is a inhibitor for MGAT5B, which catalyzes the hydrolysis of the nucleotide sugar donor substrate UDP-GlcNAc
    • cell & other
    REGULATION
    activated by CTCF and NEUROD1 (CTCF and NEUROD1 involved in the activation of MGAT5B expression)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS