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FLASH GENE

Symbol

MGAT5B

contributors: mct - updated : 22-08-2012

HGNC name	mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isoenzyme B
HGNC id	24140

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

text	alternative promoters and a dominant mRNA isoform of the gene (PMID: 21771782)

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_144677 17 - 4246 NP_653278 89 790 - Inamori NM_198955 16 - 4068 NP_945193 - 801 - Inamori NM_001199172 18 - 4252 NP_001186101 - 792 - -

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain         Homo sapiens Reproductive male system testis       Homo sapiens Visual eye

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Nervous central       Homo sapiens Nervous peripherous       Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

intraspecies

paralog to MGAT5

Homologene

FAMILY

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,Golgi
text	type II membrane protein

basic FUNCTION	DNA-dependent RNA polymerase catalyzing the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
	responsible for the synthesis of a unique oligosaccharide structure in the brain
	with POMGNT1, enzymes involved in the O-mannosyl glycosylation pathway, play an active role in modulating integrin and laminin-dependent adhesion and migration of human neuronal cells
	its expression enhances neurite outgrowth on laminin.
	synthesize both GlcNAcbeta1,6Man branched N- and O-glycans
	intrinsic and specific role in the nervous system

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	MGAT5B-mediated glycosylation of PTPRZ1 promotes galectin-1 binding and PTPRZ1 levels of retention on the cell surface
	interacting with CTCF (transcription of MGAT5B is mediated by the binding of CTCF)
	ENPP3 is a inhibitor for MGAT5B, which catalyzes the hydrolysis of the nucleotide sugar donor substrate UDP-GlcNAc

cell & other

REGULATION

activated by

CTCF and NEUROD1 (CTCF and NEUROD1 involved in the activation of MGAT5B expression)

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS