Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

MGAT5B

contributors: mct - updated : 22-08-2012

HGNC name	mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isoenzyme B
HGNC id	24140

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	81.67 kb     20 Exon(s)

regulatory sequence	Promoter
	Binding site
text structure	two nuclear proteins, CTCF and NeuroD1, which bound to and activated the promoter in neural cells

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

text	alternative promoters and a dominant mRNA isoform of the gene (PMID: 21771782)

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_144677 17 - 4246 NP_653278 89 790 - Inamori NM_198955 16 - 4068 NP_945193 - 801 - Inamori NM_001199172 18 - 4252 NP_001186101 - 792 - -

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain         Homo sapiens Reproductive male system testis       Homo sapiens Visual eye

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Nervous central       Homo sapiens Nervous peripherous       Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

intraspecies

paralog to MGAT5

Homologene

FAMILY

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,Golgi
text	type II membrane protein

basic FUNCTION	DNA-dependent RNA polymerase catalyzing the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
	responsible for the synthesis of a unique oligosaccharide structure in the brain
	with POMGNT1, enzymes involved in the O-mannosyl glycosylation pathway, play an active role in modulating integrin and laminin-dependent adhesion and migration of human neuronal cells
	its expression enhances neurite outgrowth on laminin.
	synthesize both GlcNAcbeta1,6Man branched N- and O-glycans
	intrinsic and specific role in the nervous system

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	MGAT5B-mediated glycosylation of PTPRZ1 promotes galectin-1 binding and PTPRZ1 levels of retention on the cell surface
	interacting with CTCF (transcription of MGAT5B is mediated by the binding of CTCF)
	ENPP3 is a inhibitor for MGAT5B, which catalyzes the hydrolysis of the nucleotide sugar donor substrate UDP-GlcNAc

cell & other

REGULATION

activated by

CTCF and NEUROD1 (CTCF and NEUROD1 involved in the activation of MGAT5B expression)

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS