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FLASH GENE

Symbol

CEBPG

contributors: mct/npt - updated : 05-01-2022

HGNC name	CCAAT/enhancer binding protein (C/EBP), gamma
HGNC id	1837

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral       gain of function in a subset of acute myeloid leukemia (AML) samples characterized by CEBPA hypermethylation/silencing

Susceptibility

to bronchogenic carcinoma

Variant & Polymorphism other	several polymorphisms contributing to risk for bronchogenic carcinoma (Crawford 2007)

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

Cebpg(-/-) mouse embryonic fibroblasts (MEFs) proliferated poorly, entered senescence prematurely, and expressed a proinflammatory gene signature