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FLASH GENE
Symbol CEBPG contributors: mct/npt - updated : 05-01-2022
HGNC name CCAAT/enhancer binding protein (C/EBP), gamma
HGNC id 1837
PROTEIN
PHYSICAL PROPERTIES basic
STRUCTURE
motifs/domains
  • a basic region involved in DNA binding
  • a leucine zipper motif involved in dimerization
    • mono polymer homomer , heteromer , dimer
    HOMOLOGY
    interspecies ortholog to rattus Cebpg
    ortholog to murine Cebpg
    Homologene
    FAMILY
  • bZIP family
  • C/EBP subfamily
    • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • activator of transcription
  • might change the DNA-binding specificity of other transcription factors and recruit them to unusual DNA sites
  • transcription factor primarily responsible for regulating transcription of key antioxidant and DNA repair genes in non-bronchogenic carcinoma individuals (Mullins 2005)
  • regulates ERCC5 expression and this regulation is modified by E2F1/YY1 interactions (Crawford 2007)
  • important regulator of cytokine expression in human neutrophils (Cloutier 2009)
  • CEBPG mediates the myeloid differentiation arrest induced by CEBPA deficiency in acute myeloid leukemia
  • CEBPG neutralizes the cytostatic activity of CEBPB through heterodimerization, which prevents senescence and suppresses basal transcription of SASP genes
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • homodimer
  • can form stable heterodimers with C/EBP alpha and beta and with Fos protein
    • INTERACTION
    DNA binding to the enhancer element PRE-I (positive regulatory element-I) of the IL-4 gene
    RNA
    small molecule
    protein
  • senescence-suppressing activity of CEBPG required its ability to heterodimerize with CEBPB
  • CEBPG facilitates lamellipodia formation and cancer cell migration through CERS6 upregulation
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       gain of function
    in a subset of acute myeloid leukemia (AML) samples characterized by CEBPA hypermethylation/silencing
    Susceptibility to bronchogenic carcinoma
    Variant & Polymorphism other several polymorphisms contributing to risk for bronchogenic carcinoma (Crawford 2007)
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Cebpg(-/-) mouse embryonic fibroblasts (MEFs) proliferated poorly, entered senescence prematurely, and expressed a proinflammatory gene signature