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FLASH GENE

Symbol

CEBPG

contributors: mct/npt - updated : 05-01-2022

HGNC name	CCAAT/enhancer binding protein (C/EBP), gamma
HGNC id	1837

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	8.98 kb     2 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001806 2 - 3730 NP_001797 - 150 - 1992 1377818 NM_001252296 2 - 4044 NP_001239225 - 150 - 1992 1377818

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Digestive intestine large intestine colon   moderately   pancreas exocrine       moderately Reproductive female system uterus cervix   highly   female system breast mammary gland   moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone       Nervous peripherous

cell lineage
cell lines
fluid/secretion	blood

at STAGE

PROTEIN

PHYSICAL PROPERTIES		basic
STRUCTURE

motifs/domains	a basic region involved in DNA binding
	a leucine zipper motif involved in dimerization

mono polymer

homomer , heteromer , dimer

HOMOLOGY

interspecies	ortholog to rattus Cebpg
	ortholog to murine Cebpg

Homologene

FAMILY	bZIP family
	C/EBP subfamily

CATEGORY

regulatory , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,nucleoplasm
	intracellular,nucleus,chromatin/chromosome
	intracellular,nucleus,nucleolus

basic FUNCTION	activator of transcription
	might change the DNA-binding specificity of other transcription factors and recruit them to unusual DNA sites
	transcription factor primarily responsible for regulating transcription of key antioxidant and DNA repair genes in non-bronchogenic carcinoma individuals (Mullins 2005)
	regulates ERCC5 expression and this regulation is modified by E2F1/YY1 interactions (Crawford 2007)
	important regulator of cytokine expression in human neutrophils (Cloutier 2009)
	CEBPG mediates the myeloid differentiation arrest induced by CEBPA deficiency in acute myeloid leukemia
	CEBPG neutralizes the cytostatic activity of CEBPB through heterodimerization, which prevents senescence and suppresses basal transcription of SASP genes

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	homodimer
	can form stable heterodimers with C/EBP alpha and beta and with Fos protein

INTERACTION

DNA	binding to the enhancer element PRE-I (positive regulatory element-I) of the IL-4 gene

RNA

small molecule

protein	senescence-suppressing activity of CEBPG required its ability to heterodimerize with CEBPB
	CEBPG facilitates lamellipodia formation and cancer cell migration through CERS6 upregulation

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral       gain of function in a subset of acute myeloid leukemia (AML) samples characterized by CEBPA hypermethylation/silencing

Susceptibility

to bronchogenic carcinoma

Variant & Polymorphism other	several polymorphisms contributing to risk for bronchogenic carcinoma (Crawford 2007)

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

Cebpg(-/-) mouse embryonic fibroblasts (MEFs) proliferated poorly, entered senescence prematurely, and expressed a proinflammatory gene signature