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FLASH GENE

Symbol

LPCAT3

contributors: mct - updated : 01-09-2012

HGNC name	lysophosphatidylcholine acyltransferase 3
HGNC id	30244

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	12p13.31      Physical location : 7.085.347 - 7.125.842
Synonym name	putative protein similar to nessy (Drosophila)
	O-acyltransferase domain-containing protein 5
	membrane bound O-acyltransferase domain containing 5
Synonym symbol(s)	C3F, nessy, OACT5, MBOAT5, LPLAT 5, LPSAT
EC.number	2.3.1.23

DNA

TYPE	like-sequence
STRUCTURE	40.50 kb     13 Exon(s)

regulatory sequence	Binding site   HRE
text structure	a LXRE in the promoter of the LPCAT3 (lysophosphatidylcholine acyltransferase 3)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_005768 13 - 2297 56 487 - 2008 18195019

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine small intestine     highly   liver       highly Homo sapiens   mouth tongue     highly   stomach       highly Endocrine pancreas       highly Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective adipose     highly Homo sapiens Nervous peripherous

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic neutrophil Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo

Text	mesectodermal cells at gastrulation and in mesoderm and endoderm lineages then restricted to anterior and posterior domains in the visceral mesoderm

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

asparaginase domain

HOMOLOGY

interspecies	ortholog to murine Grcc3f
	ortholog to Drosophila "Nessy"

intraspecies

homolog to LPT1

Homologene

FAMILY

membrane-bound acyltransferase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum

basic FUNCTION	involved in mesoderm and endoderm development
	primarily responsible for hepatic LPCAT activity
	plays a critical role in phosphatidylcholine remodeling in metabolic tissues and provide an invaluable tool for future investigations on how phosphatidylcholine remodeling may potentially impact glucose and lipid homeostasis
	primarily responsible for hepatic LPCAT activity
	LPCAT3 and MBOAT7 are implicated in arachidonate recycling, thus regulating free arachidonic acid levels and leukotriene synthesis in neutrophils
	lysophospholipid acyltransferase acting preferentially on lysoPC (LPC), lysoPS (LPS) and lysoPE (LPE)
	necessary role for lysophospholipid esterification in maintaining cellular function and structure
	signal-regulated enzyme that is centrally implicated in limiting free arachidonic acid levels in activated cells
	LPCAT3 and MBOAT7 are implicated in arachidonate recycling, thus regulating free arachidonic acid levels and leukotriene synthesis in neutrophils

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

development

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

Hox proteins Ultrabithorax, Antennapedia and AbdominalA

cell & other

REGULATION

repressed by

Hox proteins Ultrabithorax, Antennapedia and AbdominalA

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS