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FLASH GENE
Symbol ERLIN1 contributors: mct - updated : 30-12-2015
HGNC name ER lipid raft associated 1
HGNC id 16947
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • extreme N-terminus of ERLIN1 were found to be sufficient for heterologous targeting of GFP to the ER in the absence of classical ER retrieval motifs
    • HOMOLOGY
    interspecies ortholog to murine Spfh1
    Homologene
    FAMILY
  • band 7/mec-2 family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text membrane-associated
    basic FUNCTION
  • potential involvement in dendritic cells activation
  • ERLIN1/ERLIN2 complex is a factor that selectively mediates the ERAD of activated IP(3) receptors
  • ERLIN1, ERLIN2 promote stability of the SREBF-SCAP-INSIG complex and may contribute to the highly cooperative control of this system
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • ERLIN1/2 complex is composed of an assemblage of lower-order hetero-oligomers, probably heterotrimers, linked together by assembly domain hydrophobic AAs
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • multimeric ER proteins ERLIN1 and ERLIN2 are additional SREBF1, SREBF2 regulators
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SPG62
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS