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FLASH GENE
Symbol DGKG contributors: npt/ - updated : 15-12-2003
HGNC name diacylglycerol kinase, gamma 90kDa
HGNC id 2853
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
Visualeye    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelial    
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/Immunemacrophage
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two N terminal EF hand calcium-binding domains
  • two phorbol esters/diacylglycerol binding domains (C1 domain)
  • a DAG catalytic domain
  • a DAG accessory domain
    • HOMOLOGY
    Homologene
    FAMILY
  • eukaryotic diacylglycerol kinase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • converting diacylglycerol to phosphatidic acid
    • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    text negatively regulating macrophage differentiation of leukemic cells
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, nucleotide,
  • Ca2+
  • ATP
    • protein
    cell & other
    REGULATION
    activated by phosphatidylserine
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS