Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol DGKG contributors: npt/ - updated : 15-12-2003
HGNC name diacylglycerol kinase, gamma 90kDa
HGNC id 2853
Location 3q27.2-q27.3      Physical location : 185.864.990 - 186.080.023
Synonym name
  • diglyceride kinase gamma
  • DAG kinase gamma
    • Synonym symbol(s) DAGK3, DGK-GAMMA, MGC104993, MGC133330
    EC.number 2.7.1.107
    DNA
    TYPE functioning gene
    STRUCTURE 215.00 kb     25 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map cen - [D3S1601 - D3S3669 - OPA1 OPA1 - D3S3562 - D3S1265 ] - qter
    Authors Stör (99)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 5818 89 791 - -
    - - 5743 86.2 766 - -
    - - 5701 84.4 752 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    Visualeye    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelial    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunemacrophage
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two N terminal EF hand calcium-binding domains
  • two phorbol esters/diacylglycerol binding domains (C1 domain)
  • a DAG catalytic domain
  • a DAG accessory domain
    • HOMOLOGY
    Homologene
    FAMILY
  • eukaryotic diacylglycerol kinase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • converting diacylglycerol to phosphatidic acid
    • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    text negatively regulating macrophage differentiation of leukemic cells
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, nucleotide,
  • Ca2+
  • ATP
    • protein
    cell & other
    REGULATION
    activated by phosphatidylserine
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS