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FLASH GENE
Symbol JDP2 contributors: mct/npt/pgu - updated : 28-09-2016
HGNC name jun dimerization protein 2
HGNC id 17546
Location 14q24.3      Physical location : 75.894.508 - 75.939.402
Synonym name
  • progesterone receptor co-activator
  • Synonym symbol(s) JUNDM2
    DNA
    TYPE functioning gene
    STRUCTURE 46.02 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    ABCD4 14q24.3 ATP-binding cassette, sub-family D (ALD), member 4 C14orf115 14q24.2 chromosome 14 open reading frame 115 RPS2P2 14 ribosomal protein S2 pseudogene 2 NPC2 14q24.3 Niemann-Pick disease, type C2 HBLD1 14q24.2 HESB like domain containing 1 C14orf141 14q24.2 chromosome 14 open reading frame 141 LTBP2 14q24.3 latent transforming growth factor beta binding protein 2 KIAA0317 14q22.1-q24.3 latent transforming growth factor beta binding protein 2 C14orf111 14q24.2 chromosome 14 open reading frame 111 C14orf170 14q24.3 chromosome 14 open reading frame 170 FLJ36749 14q24.2 hypothetical protein FLJ36749 LOC390494 14 similar to DC3 DLST 14q24.3 dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) RPS6KL1 14q24.2 ribosomal protein S6 kinase-like 1 PGF 14q24.3 placental growth factor, vascular endothelial growth factor-related protein EIF2B2 14q24.3 eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa MLH3 14q24.3 mutL homolog 3 (E. coli) LOC387998 14 similar to Acylphosphatase, organ-common type isozyme (Acylphosphate phosphohydrolase) (Acylphosphatase, erythrocyte isozyme) C14orf140 14q24.2 chromosome 14 open reading frame 140 NEK9 14q24.2 NIMA (never in mitosis gene a)- related kinase 9 TMP21 14q24.3 NIMA (never in mitosis gene a)- related kinase 9 LOC338918 14q24.2 hypothetical LOC338918 FOS 14q24.3 v-fos FBJ murine osteosarcoma viral oncogene homolog LOC341912 14q24.2 similar to developmental pluripotency associated 5; embryonal stem cell specific gene 1 JDP2 14q24.3 jun dimerization protein 2 BATF 14q24 basic leucine zipper transcription factor, ATF-like C14orf58 14q24.2 chromosome 14 open reading frame 58 RPS24P2 14 ribosomal protein S24 pseudogene 2 C14orf1 14q24.3 chromosome 14 open reading frame 1 KIAA0998 14q24.3 chromosome 14 open reading frame 1 TGFB3 14q24.3 transforming growth factor, beta 3 MGC16028 14q24.3 MGC16028 similar to RIKEN cDNA 1700019E19 gene C14orf118 14q22.1-q24.3 chromosome 14 open reading frame 118 ESRRB 14q24.3 estrogen-related receptor beta
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 3793 - 163 - 2008 18671972
    4 - 3801 - 163 - 2008 18671972
    4 - 4007 - 163 - 2007 17545590
    4 - 3960 - 174 - 2008 18671972
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systembreastmammary gland moderately
    Urinarybladder   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    cell lineage
    cell lines
    fluid/secretion blood
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an N-terminal domain
  • a central basic region-leucine zipper domain
  • a putative consensus JNK docking-site
  • a corresponding phosphoacceptor site
  • a short non-conserved 4050-AAs segment between the DNA binding domain and the ligand binding domain (LBD), termed the C-terminal extension (CTE), playing a role as a binding site for co-activator proteins
  • mono polymer homomer , heteromer , dimer
    HOMOLOGY
    interspecies ortholog to rattus Jundp2
    ortholog to murine Jundm2
    Homologene
    FAMILY
  • bZIP family
  • member of the AP-1 (activating protein-1) family of the basic leucine zipper transcription factors
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • involved in the regulation of transcription, DNA-dependent
  • inhibitory subunit of the differentiation regulatory factor (DRF) complex
  • may play an important role in the RANK-mediated signal transduction system, especially in osteoclast differentiation
  • acting as a repressor functionally associated with HDAC3 to inhibit DDIT3 transcription
  • cooperates with various proteins to mediate regulatory activity
  • inhibitor of acetylation of histones and contributes to the maintenance of chromatin structure
  • plays a key role as a repressor of adipocyte differentiation by regulating the expression of the gene for C/EBPdelta via inhibition of histone acetylation
  • progesterone receptor-interacting protein enhancing the transcriptional activity of the N-terminal domain and can act in a manner independent of the ligand binding domain AF2
  • role as a regulator of the progression of normal cells through the cell cycle
  • AP1 family transcription factor that regulates the epigenetic status of histones
  • controls bone homeostasis and antibacterial immunity by regulating osteoclast and neutrophil differentiation
  • JDP2 plays a critical role as a cofactor NFE2L2 and MAFK in the regulation of the antioxidants and production of reactive oxygen species (ROS)
  • typically suppresses gene transcription through multiple mechanisms and plays a dual role in multiple cellular processes, including cell differentiation and proliferation which is dependent on AP1 function
  • plays a role as a histone chaperone and participates in diverse processes, such as cell-cycle arrest, cell differentiation, apoptosis, senescence, and metastatic spread, and functions as an oncogene and anti-oncogene, and as a cellular reprogramming factor
  • specific role of JDP2 in cellular-stress regulation and prevention
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • dimerizes with other AP-1 proteins such as activating transcription factor-2 (ATF2)
  • JDP2 is an integral component of the NFE2L2-MAFK complex and it modulates antioxidant and detoxification programs by acting via the antioxidant-responsive element (ARE)
  • INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • recruited to the promoter of the gene for cyclin-A2 (CCNA2) at the AP-1 site (transcription of the gene for CCNA2 appears to be a direct target of JDP2 in the suppression of cell proliferation)
  • association of HDAC3 and HDAC6 with JDP2 and ATF3 occurs via direct protein-protein interactions
  • ATF3 was an inhibitor of neutrophil differentiation and JDP2 directly suppresses its expression via inhibition of histone acetylation
  • JDP2 associates with NFE2L2 and MAFK (NFE2L2-MAFK) to increase the transcription of antioxidant response element-dependent genes
  • JDP2 bound directly to the ARE core sequence, associated with NFE2L2 and MAFK (NFE2L2-MAFK) via basic leucine zipper domains, and increased DNA-binding activity of the NFE2L2-MAFK complex to the ARE and the transcription of ARE-dependent genes
  • TBX3 plays an important role in osteoclastogenesis at least in part by regulating CSF1-dependent expression of JDP2
  • DCLK1 efficiently phosphorylates JDP2, a possible target in the nucleus, with the aid of histones
  • cell & other
    REGULATION
    repressed by TP53 that significantly repressed the transcriptional activity of the JDP2 promoter
    Phosphorylated by on Thr148 by JNK (c-Jun N-terminal kinase) and MAPK14, although the functional role of its phosphorylation is targeting it for proteosomal degradation
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • mice lacking Jdp2 (Jdp2-/-) display a reduced rate of metastasis in Lewis lung carcinoma (LLC) and polyoma middle T-antigen (PyMT) breast carcinoma mouse models
  • Jdp2(-/-) mice exhibited osteopetrosis resulting from impaired osteoclastogenesis