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FLASH GENE
Symbol RPS7 contributors: mct - updated : 11-01-2023
HGNC name ribosomal protein S7
HGNC id 10440
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated Other
mono polymer complex
HOMOLOGY
interspecies homolog to rattus Rps7 (100 pc)
homolog to murine Rps7 (100 pc)
Homologene
FAMILY
  • ribosomal protein S7e family
    • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,ribosome
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    intracellular,nucleus,nucleolus
    text
  • SRY, RPS7 and RPL13A were co-localized in nuclear speckles
    • basic FUNCTION
  • being a structural constituent of ribosome
  • acting as a modulator of p53-MDM2 interaction
  • having an essential role for proliferation in all cells (Robledo 2008)
  • functions as both effector and affector of MDM2 to ensure a proper cellular response to different stress signals
  • novel function of RPS7 in control of GADD45A stabilization under both basal and stress conditions
  • suppresses ovarian tumorigenesis and metastasis through PI3K/AKT and MAPK signal pathways
    • CELLULAR PROCESS protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • small ribosomal subunit
  • acetylation
    • INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • binding to IPO9 with high affinity
  • MDM2 ubiquitination of RPSS7 is involved in sustaining the TP53 response
  • RPS7 (ribosomal protein S7) and RPL13a (ribosomal protein L13a) interact with the HMG (high-mobility group) box domain of SRY
  • MDM2-binding partner, interacting with and stabilizing GADD45A through preventing the ubiquitination and degradation of GADD45A mediated by MDM2
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DBA8
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • may be used as a potential marker for diagnosis and treatment of ovarian cancer
    • Therapy target
    ANIMAL & CELL MODELS