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FLASH GENE

Symbol

PLEKHG4

contributors: mct/npt - updated : 25-08-2015

HGNC name	pleckstrin homology domain containing, family G (with RhoGef domain) member 4
HGNC id	24501

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	one PH domain
	a spectrin repeat
	a guanine-nucleotide exchange factor (GEF) for Rho GTPases
	a Dbl-homologous domain
	the cellular retinaldehyde-binding (CRAL)/triple function domain (TRIO) (at codons 304338)

conjugated

PhosphoP

HOMOLOGY

interspecies	ortholog to chimpanzee LOC454164
	ortholog to murine Plekhg4

Homologene

FAMILY

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	playing a role in intracellular signaling and actin dynamics at the Golgi apparatus (Ishikawa 2005)
	functions as a bona fide guanine nucleotide exchange factor (GEF) that facilitates activation of the small GTPases RAC1, CDC42, and RHOA
	aggregation-prone member of the Dbl family GEFs

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	interacting with ATXN1
	PLEKHG4 regulates RAC1 downstream of AKT2, leading to the stimulation of glucose uptake in skeletal muscle

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS