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FLASH GENE
Symbol RCAN1 contributors: mct/pgu/shn - updated : 13-09-2023
HGNC name regulator of calcineurin 1
HGNC id 3040
ANIMAL & CELL MODELS
  • overexpressed in the brain of Down syndrome fetuses
  • lack of MCIP1 exacerbated the hypertrophic response to activated calcineurin expressed from a muscle-specific transgene
  • RCAN1 knockout mice exhibited an attenuated mesenteric vasoconstriction to phenylephrine as compared with wild-type
  • H2O2 induces decrease in RCAN1 in hippocampal and cortical neurons
  • RCAN1-TG mice display T cell developmental defects in the thymus and peripheral immune tissues
  • modestly increased Rcan1 expression afforded by a single extra copy is sufficient to suppress pancreatic tumorigenesis mediated by oncogenic KrasG12D in mice through attenuation of calcineurin–NFAT signaling