Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

RCAN1

contributors: mct/pgu/shn - updated : 13-09-2023

HGNC name	regulator of calcineurin 1
HGNC id	3040

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

TRI21

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   chronic overexpression associated with Alzheimer disease or Down syndrome progression, and contributes to neuronal dysfunction in these neurological disorders constitutional     --over   increases neuronal susceptibility to oxidative stress constitutional     --over   in brains of Down syndrome fetuses, and in the cerebral cortex and hippocampus of sporadic AD patients constitutional     --over   promoted endothelial cell proliferation and angiogenesis constitutional     --over   increased expression of in individuals with trisomy 21 is probably a significant contributor to the decreased cancer incidence in this population constitutional     --over   in primary neurons activates caspase-9 and caspase-3 and subsequently induces neuronal apoptosis constitutional     --over   may contribute to AD pathogenesis by mediating neuronal death in the brains of DS and AD patients constitutional     --over   overexpression of RCAN1, as observed in DS and AD, may enhance CREB1 signaling by blocking calcineurin activity constitutional       loss of function can contribute to Huntington disease tumoral     --over   markedly reduced glioma cells viability

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed neurology neurodegenerative   therapeutic targets in the context of neurodegenerative processes cancer angiogenesis   signaling pathway that regulates RCAN1 expression are excellent targets for cancer anti-angiogenic therapy cancer     calcineurin signalling pathway, and its regulators RCAN1 and DYRK1A, are potential therapeutic targets in cancers arising in all individuals neurology     potential new target for treating calcineurin-related brain disorders neurology neurodegenerative alzheimer potential of targeting RCAN1 as a new therapeutic approach

ANIMAL & CELL MODELS

	overexpressed in the brain of Down syndrome fetuses
	lack of MCIP1 exacerbated the hypertrophic response to activated calcineurin expressed from a muscle-specific transgene
	RCAN1 knockout mice exhibited an attenuated mesenteric vasoconstriction to phenylephrine as compared with wild-type
	H2O2 induces decrease in RCAN1 in hippocampal and cortical neurons
	RCAN1-TG mice display T cell developmental defects in the thymus and peripheral immune tissues
	modestly increased Rcan1 expression afforded by a single extra copy is sufficient to suppress pancreatic tumorigenesis mediated by oncogenic KrasG12D in mice through attenuation of calcineurin–NFAT signaling