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FLASH GENE
Symbol DNAJC19 contributors: mct - updated : 18-08-2010
HGNC name DnaJ (Hsp40) homolog, subfamily C, member 19
HGNC id 30528
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to yeast inner mitochondrial cochaperones
ortholog to yeast Pam18
Homologene
FAMILY
  • TIM14 family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    intracellular,nucleus
    basic FUNCTION
  • constituent of the mitochondrial import motor required for the activation of mtHsp70
  • required for the translocation of transit
    • peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner
  • may act as a co-chaperone that stimulate the ATP-dependent activity
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • probable component of the PAM complex at least composed of a mitochondrial HSP70 protein, GRPEL1 or GRPEL2, TIMM44,
    • TIMM16/MAGMAS and TIMM14/DNAJC19
  • MAGMAS:DNAJC19 subcomplex is associated with TIMM23 complex and thus regulates mitochondrial import process (Sinha 2010)
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with TIMM44 and mtHsp70 in an ATP-dependent manner
  • stable interaction between MAGMAS and DNAJC19 that plays a crucial role in tethering of DNAJC19 at the translocon and perhaps regulating human import motor activity (Sinha 2010)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CMDA
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS