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FLASH GENE
Symbol DNAJC19 contributors: mct - updated : 18-08-2010
HGNC name DnaJ (Hsp40) homolog, subfamily C, member 19
HGNC id 30528
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 1476 - 116 - Mokranjac (2003)
also called TIM14 variant 1
5 - 1488 - 91 - Mokranjac (2003)
also called TIM14 variant 2
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine   
 intestinelarge intestinecolon  
 salivary gland   highly
Endocrineneuroendocrinepituitary  highly
Reproductivemale systemprostate  highly
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to yeast inner mitochondrial cochaperones
ortholog to yeast Pam18
Homologene
FAMILY
  • TIM14 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    intracellular,nucleus
    basic FUNCTION
  • constituent of the mitochondrial import motor required for the activation of mtHsp70
  • required for the translocation of transit
  • peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner
  • may act as a co-chaperone that stimulate the ATP-dependent activity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • probable component of the PAM complex at least composed of a mitochondrial HSP70 protein, GRPEL1 or GRPEL2, TIMM44,
  • TIMM16/MAGMAS and TIMM14/DNAJC19
  • MAGMAS:DNAJC19 subcomplex is associated with TIMM23 complex and thus regulates mitochondrial import process (Sinha 2010)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with TIMM44 and mtHsp70 in an ATP-dependent manner
  • stable interaction between MAGMAS and DNAJC19 that plays a crucial role in tethering of DNAJC19 at the translocon and perhaps regulating human import motor activity (Sinha 2010)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CMDA
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS