Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Orphanet	Ensembl
	HGNC	UniGene	Nucleotide	OMIM		UCSC

Home Page

FLASH GENE

Symbol

DNAJC19

contributors: mct - updated : 18-08-2010

HGNC name	DnaJ (Hsp40) homolog, subfamily C, member 19
HGNC id	30528

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	6.07 kb     6 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_145261 6 - 1476 NP_660304 - 116 - Mokranjac (2003) also called TIM14 variant 1 NM_001190233 5 - 1488 NP_001177162 - 91 - Mokranjac (2003) also called TIM14 variant 2

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine small intestine         intestine large intestine colon       salivary gland       highly Endocrine neuroendocrine pituitary     highly Reproductive male system prostate     highly Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow       Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies	homolog to yeast inner mitochondrial cochaperones
	ortholog to yeast Pam18

Homologene

FAMILY

TIM14 family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria,inner
	intracellular,cytoplasm,organelle,membrane
	intracellular,nucleus

basic FUNCTION	constituent of the mitochondrial import motor required for the activation of mtHsp70
	required for the translocation of transit
	peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner
	may act as a co-chaperone that stimulate the ATP-dependent activity

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	probable component of the PAM complex at least composed of a mitochondrial HSP70 protein, GRPEL1 or GRPEL2, TIMM44,
	TIMM16/MAGMAS and TIMM14/DNAJC19
	MAGMAS:DNAJC19 subcomplex is associated with TIMM23 complex and thus regulates mitochondrial import process (Sinha 2010)

INTERACTION

DNA

RNA

small molecule

protein	interacting with TIMM44 and mtHsp70 in an ATP-dependent manner
	stable interaction between MAGMAS and DNAJC19 that plays a crucial role in tethering of DNAJC19 at the translocon and perhaps regulating human import motor activity (Sinha 2010)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

CMDA

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS